TNBS/DNBS-Induced Rodent Colitis Model
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| Feb 17th, 23:32 | |
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The TNBS colitis model is widely used in preclinical studies to evaluate the pathogenesis of inflammatory bowel disease (IBD) and test potential therapeutic interventions. This model, induced by the administration of trinitrobenzenesulfonic acid (TNBS), mimics many of the key features of human colitis, including mucosal inflammation, ulceration, and tissue damage. Researchers often use the TNBS colitis model to study the mechanisms behind gut inflammation and explore treatments that may help manage or cure IBD. It serves as a critical tool for understanding immune responses in the gut and for the development of new drugs targeting intestinal disorders. |
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